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Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T cell function [scRNA/CITE-seq]

UID: 11218

Author(s): Jain, Nayan*, Zhao, Zeguo*, Antelope, Chenling, Gozlan, Yosi, Montalbano, Antonino, Brocks, David, Dobrin, Anton*, Lopez, Michael*, Sadelain, Michel W. J.* * MSK affiliated

Description
Summary from GEO:

"Single cell gene expression profile of WT and SUV39H1-edited CAR T cells at pre-infusion (Day 0), day 9 and day 16 post infusion in tumor (NALM6) bearing NSG mice"

Overall design from GEO:

"Unedited and SUV39H1-edited human CAR T cells were sorted from bone marrow (at day 9 and 16) from tumor bearing NSG mice. Pre-infusion single cell gene expression profiling of unedited and SUV39H1-edited human CAR T cells was also performed."
Subject of Study
Homo sapiens
Subject(s)
Gene Expression Profiling
Genomics
Methylation
Receptors, Chimeric Antigen
Access via GEO


Accession #: GSE246960

Access via BioProject


Accession #: PRJNA1035433

Access Restrictions
Free to All
Access Instructions
The NCBI Gene Expression Omnibus and BioProject databases provide open access to these files.
Associated Publications
Jain N, Zhao Z, Koche R, Antelope C, Gozlan Y, Montalbano A, Brocks D, Lopez M, Dobrin A, Shi Y, Gunset G, Giavridis T, Sadelain M. Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T-cell function. Cancer Discovery. 2024; 14(1):142-157.
Equipment Used
Illumina NovaSeq 6000
Dataset Format(s)
RDS
Dataset Size
1.5 GB
Data Catalog Record Updated
2024-04-02