Effect of loss of Jmjd1c on MLL-AF9 leukemia

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UID: 11230

Author(s): Zhu, Nan*, Rahnamay, Noushin F.*, Sinha, Amit U.*, Koche, Richard Patrick*, Armstrong, Scott Allen* * MSK affiliated

Description: Summary from GEO:

"Analysis of gene expression profile of MLL-AF9 leukemia cells 6 days after loss of Jmjd1c. Loss of Jmjd1c induces differentiation and apoptosis in MLL-AF9 leukemia cells. These results provide insight into the role of Jmjd1c in MLL leukemia."

Overall design from GEO:

"We used primary Jmjd1c f/f MLL-AF9-GFP leukemia cells from four leukemic mice and delivered Cre-Tomato by retroviral infection. Cells infected with virus made from empty vector was used as control. We sorted GFP and Tomato double positive cells 6 days after Cre infection and subjected the samples to RNA-seq."

Subject of Study

Subject(s)

OncoTree Cancer Type(s)

Acute Myeloid Leukemia

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