Effect of loss of Jmjd1c on H3K9me2 level across the genome

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UID: 11231

Author(s): Zhu, Nan*, Rahnamay, Noushin F.*, Sinha, Amit U.*, Koche, Richard Patrick*, Armstrong, Scott Allen* * MSK affiliated

Description: Summary from GEO:

"Analysis of H3K9me2 level in MLL-AF9 leukemia cells upon deletion of Jmjd1c. Jmjd1c has been shown to be a H3K9me1/2 demethylase and these results provide insight into its role in MLL-Af9 leukemia"

Overall design from GEO:

"We used primary Jmjd1c f/f MLL-AF9-GFP leukemia cells and delivered Cre-Tomato retroviral infection. Cells infected with virus made from empty vector was used as control (MIT). We sorted GFP and Tomato double positive cells 6 days after infection and subjected the samples to ChIP-seq. We also carried out ChIP-seq in single cell clone (SSC) derived from methylcult culture of Jmjd1c f/f MLL-AF9-GFP/ Cre cells."

Subject of Study

Subject(s)

OncoTree Cancer Type(s)

Acute Myeloid Leukemia

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