Effect of loss of Jmjd1c on normal hematopoiesis

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UID: 11232

Author(s): Zhu, Nan*, Rahnamay, Noushin F.*, Sinha, Amit U.*, Koche, Richard Patrick*, Armstrong, Scott Allen* * MSK affiliated

Description: Summary from GEO:

"Analysis of gene expression profile of LSK (Lin-Sca-1+ c-Kit+) isolated from Jmjd1c f/f Vav1Cre or Vav1Cre controls. Loss of Jmjd1c minimally affected HSC in homeostatsis while impiars HSC function in response to stree such as transplantation and 5-Fu treatment. These results provide insight into the role of Jmjd1c in normal hematopoiesis."

Overall design from GEO:

"LSK cells were isolated from bone marrow of seven weeks old Jmjd1c f/f Vav1Cre or Vav1Cre controls mice by flow acivated cell sorting and subjected to RNA-seq."

Subject of Study

Subject(s)

OncoTree Cancer Type(s)

Acute Myeloid Leukemia

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