WGS short read and 10X linked read sequencing of HR Deficient breast cancers

UID: 11269

Publisher(s): European Genome-phenome Archive

Description: Description from EGA:

"A set of tumor/normal paired sequencing experiments, performed in short read WGS and 10X linked read whole genomes.
BAM files aligned to hg19 are provided.
Sample Alias number and Subject ID reflects patient of origin. T/N distinction discriminates between tumor and normal (peripheral blood) tissue."

Subject(s)

Access via EGA

Accession #: EGAD00001010326
Access Restrictions: Application Required
Access Instructions: It is possible to submit an access request to data stored at the EGA. The DAC assigned to the study will assess the request and, if approved, grant access to the data. Requesters must provide sufficient justification for your request and comply with the intended data usage in order to get access to it.

Each dataset is covered by a Data Access Agreement (DAA) that defines the terms and conditions of use for the specified datasets. The DAA is created and provided by the DAC, and must be signed by the individual requesting access to the given dataset.
Associated Publications: Setton J, Hadi K, Choo Z, Kuchin K, Tian H, Da Cruz Paula A, Rosiene J, Selenica P, Behr J, Yao X, Deshpande A, Sigouros M, Manohar J, Nauseef J, Mosquera J, Elemento O, Weigelt B, Riaz N, Reis-Filho J, Powell S, Imieliński M. Long-molecule scars of backup DNA repair in BRCA1- and BRCA2-deficient cancers. Nature. 2023; 621(7977):129-137.

Choo Z, Behr J, Deshpande A, Hadi K, Yao X, Tian H, Takai K, Zakusilo G, Rosiene J, Da Cruz Paula A, Weigelt B, Setton J, Riaz N, Powell S, Busam K, Shoushtari A, Ariyan C, Reis-Filho J, de Lange T, Imieliński M. Most large structural variants in cancer genomes can be detected without long reads. Nature Genetics. 2023; 55(12):2139-2148.
Equipment Used: Illumina NovaSeq 6000
Dataset Format(s): BAM
Dataset Size: 21.7 TB

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