JaBbA (Junction Balance Analysis)

Default Boolean Operator: Terms in a search string will be connected by the AND operator, EXAMPLE: searching genomic melanoma will produce the same results as genomic AND melanoma .
AND, OR, NOT: Combine terms in a search with the boolean operators AND (to add specificity), OR (to broaden), or NOT (to eliminate a term). Operators must be capitalized (all other search terms are not case-sensitive).
Wild Card: Add wild card symbols * (open-ended) and ? (single character) to truncate terms. EXAMPLE: searching gen* shows results for 'gene', 'genetic', 'genomic, etc. Searching gene? returns results for 'gene' or 'genes' but not for 'genome'.
Phrase Searching: Enclose search in quotation marks "keyword or search term" to search for an exact phrase. EXAMPLE: "transcription factors" returns results for records where transcription is immediately followed by the word factors .
Diacritics: Words containing diacritics translate those characters to non-diacritic form. EXAMPLE: massague returns results for Massague&#769 .
Filter by: Located on the homepage (left panel), use filters to search for records or narrow the search. From search results page, filters can be removed by clicking on the term at the top of the page.

UID: 11272

Author(s): Imielinski, Marcin

Description: Description from GitHub:

"JaBbA builds a genome graph based on junctions and read depth from whole genome sequencing, inferring optimal copy numbers for both vertices (DNA segments) and edges (bonds between segments). It can be used for discovering various patterns of structural variations.

If you use JaBbA in your work, please cite: Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs"

Subject(s)

Access via GitHub
Access Restrictions: Free to All
Access Instructions: Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the relevant conditions. Read more about access policy on GitHub.
Associated Publications: Setton J, Hadi K, Choo Z, Kuchin K, Tian H, Da Cruz Paula A, Rosiene J, Selenica P, Behr J, Yao X, Deshpande A, Sigouros M, Manohar J, Nauseef J, Mosquera J, Elemento O, Weigelt B, Riaz N, Reis-Filho J, Powell S, Imieliński M. Long-molecule scars of backup DNA repair in BRCA1- and BRCA2-deficient cancers. Nature. 2023; 621(7977):129-137.

Hadi K, Yao X, Behr J, et al. Distinct classes of complex structural variation uncovered across thousands of cancer genome graphs. Cell. 2020; 183(1):197-210.e32.
Software Used: R
a free software environment for statistical computing and graphics.
Dataset Format(s): R, TXT, BW, RDS, RST

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