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Mutational Landscape Determines Sensitivity to PD-1 Blockade in Non-Small Cell Lung Cancer

UID: 11286

Author(s): Chan, Timothy A.*, Hellmann, Matthew D.* * MSK affiliated

Description
From the dbGaP study description:

"Patients with non-small cell lung cancer were treated with pembrolizumab. Their tumors and matched normal blood were sequenced."
Subject of Study
Homo sapiens
Subject(s)
Carcinoma, Non-Small-Cell Lung
Drug Therapy
Immune Checkpoint Inhibitors
Mutation
Access via dbGaP


Accession #: phs000980.v1.p1

Access Restrictions
Application Required
Access Instructions
Full access to this dataset in dbGaP requires authorization through an Authorized Access Portal which can be requested for either 'data download' or 'view only'. Individual level data download requires a project request. With dbGaP DataBrowser approval, users may view the compilation of individual-level data of general research use. Upon approval, data can be downloaded. To view the data available with Authorized Access, click the link 'list of components' in the Authorized Access section. Upon approval, data can be downloaded.

Publicly available data such as data dictionaries, variable summaries, documents and truncated analysis are available the public download site FTP link.
Associated Publications
Rizvi N, Hellmann M, Snyder A, Kvistborg P, Makarov V, Havel J, Lee W, Yuan J, Wong P, Ho T, Miller M, Rekhtman N, Moreira A, Ibrahim F, Bruggeman C, Gasmi B, Zappasodi R, Maeda Y, Sander C, Garon E, Merghoub T, Wolchok J, Schumacher T, Chan T. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015; 348(6230):124-128.
Luksza M, Riaz N, Makarov V, Balachandran V, Hellmann M, Solovyov A, Rizvi N, Merghoub T, Levine A, Chan T, Wolchok J, Greenbaum B. A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy. Nature. 2017; 551(7681):517-520.
Equipment Used
Illumina HiSeq 2000

High throughput gene sequencing system

Dataset Format(s)
PDF, XML, TAR, gzip, TXT
Dataset Size
1.28 MB
Data Catalog Record Updated
2024-06-19