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Bladder Chemotherapy Responders

UID: 11290

Author(s): Garraway, Levi A., Rosenberg, Jonathan Eric* * MSK affiliated

Description
Description from dbGaP:

"Cisplatin-based chemotherapy is the standard of care for patients with muscle invasive urothelial carcinoma. Pathologic downstaging to pT0/pTis after neoadjuvant cisplatin-based chemotherapy is associated with improved survival, and some patients with metastatic disease achieve complete responses to these therapies. However, the molecular determinants of cisplatin response are incompletely understood. We performed whole exome sequencing on tumor and germline DNA from patients with muscle invasive or metastatic urothelial carcinoma who received cisplatin-based chemotherapy to identify somatic mutations that occurred preferentially in cisplatin responders."
Subject of Study
Subject(s)
Access via dbGaP


Accession #: phs000771.v2.p1

Access Restrictions
Application Required
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Associated Publications
Equipment Used
Agilent SureSelect Human All Exon V2
Dataset Format(s)
PDF, XML, TAR, gzip, TXT
Dataset Size
1.94 MB
Data Catalog Record Updated
2024-07-05