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Lobular Carcinomas In Situ Display Intra-Lesion Genetic Heterogeneity and Clonal Evolution in the Progression to Invasive Disease

UID: 11291

Author(s): King, Tari A.*, Reis-Filho, Jorge S.* * MSK affiliated

Description
Description from dbGaP:

"This study comprises prospectively accrued, microdissected fresh frozen samples of multifocal lobular carcinoma in situ (LCIS), ductal carcinoma in situ (DCIS), invasive lobular carcinoma and invasive ductal carcinoma from patients undergoing prophylactic or therapeutic mastectomies after a diagnosis on LCIS diagnosed and managed at Memorial Sloan Kettering Cancer Center (MSKCC). Microdissected samples were subjected to paired-end whole exome sequencing on an Illumina HiSeq 2000. The data generated were used to define the landscape of somatic genetic alterations of LCIS, DCIS, invasive lobular carcinoma and invasive ductal carcinoma, to define clonal relatedness of these lesions and to investigate the clonal shifts in the progression from in situ to invasive breast cancer."
Subject of Study
Subject(s)
OncoTree Cancer Type(s)
Breast Ductal Carcinoma In Situ
Breast Lobular Carcinoma In Situ
Access via dbGaP


Accession #: phs001006.v1.p1

Access Restrictions
Application Required
Access Instructions
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Associated Publications
Equipment Used
Illumina HiSeq 2000
Dataset Format(s)
PDF, XML, gzip, TXT
Dataset Size
189.84 KB
Data Catalog Record Updated
2024-07-05