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National Cancer Institute (NCI) Non-Hodgkin Lymphoma Genome-Wide Association Study (GWAS)

UID: 11293

Author(s): Berndt, Sonja, Rothman, Nathaniel, Chanock, Stephen, Lan, Qing, Teras, Lauren, Vineis, Paolo, Birmann, Brenda, Severi, Gianluca, Zeleniuch-Jacquotte, Anne, Purdue, Mark, Brooks-Wilson, Angela R., Roman, Eve, Cocco, Pierluigi, Hartge, Patricia, Armstrong, Bruce, Smedby, Karin, Skibola, Christine, Zhang, Yawei, Monnereau, Alain, Nieters, Alexandra, Cerhan, James, Slager, Susan, Joseph, Vijai*, Wang, Zhaoming * MSK affiliated

Description
Description from dbGaP:

"Within the framework of the International Lymphoma Epidemiology Consortium (InterLymph) Consortium and NCI-sponsored Cohort Consortium, investigators from 22 studies came together to conduct a genome-wide association study (GWAS) of non-Hodgkin lymphoma (NHL). The goal of the study was to identify common genetic variants associated with the risk of NHL. As described previously (Berndt SI et al., Nature Genetics, 2013, PMID: 23770605 ), cases and controls from 22 studies, including nine prospective cohort studies, eight population-based case-control studies, and five clinic or hospital-based case-control studies were included in this effort. Cases of NHL were ascertained from cancer registries, clinics or hospitals, or through self-report verified by medical and pathology reports. The phenotype information for all NHL cases was reviewed centrally at the InterLymph Data Coordinating Center and harmonized according to the hierarchical classification proposed by the InterLymph Pathology Working Group based on the World Health Organization (WHO) classification (2008). Controls were frequency matched to cases on age and gender by study, and the study was limited to subjects of European ancestry. Participants were genotyped using the Illumina Omni Express."

This study has the following substudies, also available through the dbGaP page:
phs000802 NCI Non-Hodgkin Lymphoma GWAS: CLL
phs000818 NCI Non-Hodgkin Lymphoma GWAS: Controls
phs000889 NCI Non-Hodgkin Lymphoma GWAS: DLBCL
phs000890 NCI Non-Hodgkin Lymphoma GWAS: FL
phs000891 NCI Non-Hodgkin Lymphoma GWAS: MZL
Subject of Study
Homo sapiens
Subject(s)
Genomics
Lymphoma, Non-Hodgkin
OncoTree Cancer Type(s)
Non-Hodgkin Lymphoma
Access via dbGaP


Accession #: phs000801.v2.p1

Access Restrictions
Application Required
Access Instructions
Full access to this dataset in dbGaP requires authorization through an Authorized Access Portal which can be requested for either 'data download' or 'view only'. Authorized access requests for the substudies of this study should be made through the portal for phs000801.v2.p1. Individual level data download requires a project request. With dbGaP DataBrowser approval, users may view the compilation of individual-level data of general research use. Upon approval, data can be downloaded. To view the data available with Authorized Access, click the link 'list of components' in the Authorized Access section. Upon approval, data can be downloaded.

Publicly available data such as data dictionaries, variable summaries, documents and truncated analysis are available the public download site FTP link.
Associated Publications
Berndt S, Skibola C, Joseph V, et al. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Nature Genetics. 2013; 45(8):868-876.
Cerhan J, Berndt S, Vijai J, et al. Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Nature Genetics. 2014; 46(11):1233-1238.
Vijai J, Wang Z, Berndt S, et al. A genome-wide association study of marginal zone lymphoma shows association to the HLA region. Nature Communications. 2015; 6:5751.
Skibola CF, Berndt SI, Vijai J, et al. Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region. Am J Hum Genet. 2014 Oct 2;95(4):462-71.
Equipment Used
Illumina HumanOmniExpress-12v1.0

Array

Dataset Format(s)
PDF, XML, TAR, gzip, TXT
Dataset Size
165.97 GB
Data Catalog Record Updated
2024-07-08