Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses
UID: 11294
- Description
- Description from dbGaP:
"We show that DNA methyltransferase inhibitors (DNMTis) upregulate immune signaling in cancer through the viral defense pathway and re-expression of epigenetically silenced endogenous retrovirus. In melanoma patients treated with an immune checkpoint therapy, high viral defense signature expression in tumors significantly associates with durable clinical response and DNMTi treatment sensitizes to anti-CTLA4 therapy in a pre-clinical melanoma model."
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Access via dbGaP
Accession #: phs001038.v1.p1 - Access Restrictions
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Application Required
- Access Instructions
- Full access to this dataset in dbGaP requires authorization through an Authorized Access Portal which can be requested for either 'data download' or 'view only'. Individual level data download requires a project request. With dbGaP DataBrowser approval, users may view the compilation of individual-level data of general research use. Upon approval, data can be downloaded. To view the data available with Authorized Access, click the link 'list of components' in the Authorized Access section. Upon approval, data can be downloaded.
Publicly available data such as data dictionaries, variable summaries, documents and truncated analysis are available the public download site FTP link. - Associated Publications
- Equipment Used
- Dataset Format(s)
- PDF, XML, TAR, gzip, TXT
- Dataset Size
- 14.05 MB
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