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Exome recapture and sequencing of prospectively characterized clinical specimens from cancer patients

UID: 11301

Author(s): Taylor, Barry Stephen*, Drilon, Alexander E.*, Rosen, Ezra Y.*, D'Angelo, Sandra Pierina*, Al-Ahmadie, Hikmat*, Schultz, Nikolaus D.*, Donoghue, Mark T. A.* * MSK affiliated

Description
Description from dbGaP:

"The study cohort comprises samples from patients whose tumors have been prospectively characterized as part of their care at Memorial Sloan Kettering Cancer Center. This includes a variety of distinct tumor type and molecular subtypes."
Subject of Study
Homo sapiens
Subject(s)
Exome Sequencing
Neoplasms/genetics
Access via dbGaP


Accession #: phs001783.v6.p1

Access Restrictions
Application Required
Access Instructions
Full access to this dataset in dbGaP requires authorization through an Authorized Access Portal which can be requested for either 'data download' or 'view only'. Individual level data download requires a project request. With dbGaP DataBrowser approval, users may view the compilation of individual-level data of general research use. Upon approval, data can be downloaded. To view the data available with Authorized Access, click the link 'list of components' in the Authorized Access section. Upon approval, data can be downloaded.

Publicly available data such as data dictionaries, variable summaries, documents and truncated analysis are available the public download site FTP link.
Associated Publications
Jonsson P, Bandlamudi C, Cheng M, Srinivasan P, Chavan S, Friedman N, Rosen E, Richards A, Bouvier N, Selcuklu S, Bielski C, Abida W, Mandelker D, Birsoy O, Zhang L, Zehir A, Donoghue M, Baselga J, Offit K, Scher H, O’Reilly E, Stadler Z, Schultz N, Socci N, Viale A, Ladanyi M, Robson M, Hyman D, Berger M, Solit D, Taylor B. Tumour lineage shapes BRCA-mediated phenotypes. Nature. 2019; 571(7766):576-579.
Equipment Used
Agilent SureSelect Human All Exon V4
Illumina HiSeq 2500

High throughput sequencing system

Illumina HiSeq 4000

High throughput gene sequencing system

Illumina NovaSeq 6000
xGen Exome Research Panel

Exome capture kit for target capture.

Dataset Format(s)
PDF, XML, gzip, TXT
Dataset Size
503.18 KB
Data Catalog Record Updated
2024-07-12