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Chemosensitive Relapse in Small Cell Lung Cancer Patient-Derived Xenografts

UID: 11303

Author(s): Poirier, John T.

Description
Description from dbGaP:

"Genetic and epigenetic analysis of patient-derived xenograft models of acquired chemoresistance in small cell lung cancer."
Subject of Study
Homo sapiens
Subject(s)
Drug Resistance, Neoplasm
Epigenetics
Neoplasms/genetics
Small Cell Lung Carcinoma
OncoTree Cancer Type(s)
Small Cell Lung Cancer
Access via dbGaP


Accession #: phs001249.v1.p1

Access Restrictions
Application Required
Access Instructions
Full access to this dataset in dbGaP requires authorization through an Authorized Access Portal which can be requested for either 'data download' or 'view only'. Individual level data download requires a project request. With dbGaP DataBrowser approval, users may view the compilation of individual-level data of general research use. Upon approval, data can be downloaded. To view the data available with Authorized Access, click the link 'list of components' in the Authorized Access section. Upon approval, data can be downloaded.

Publicly available data such as data dictionaries, variable summaries, documents and truncated analysis are available the public download site FTP link.
Associated Publications
Gardner E, Lok B, Schneeberger V, Desmeules P, Miles L, Arnold P, Ni A, Khodos I, de Stanchina E, Nguyen T, Sage J, Campbell J, Ribich S, Rekhtman N, Dowlati A, Massion P, Rudin C, Poirier J. Chemosensitive relapse in small cell lung cancer proceeds through an EZH2-SLFN11 axis. Cancer Cell. 2017; 31(2):286-299.
Equipment Used
Agilent SureSelect Human All Exon V4
Illumina HiSeq 2500

High throughput sequencing system

MSK-IMPACT

a hybridization capture-based next-generation sequencing assay for targeted deep sequencing of all exons and selected introns of 341 key cancer genes in formalin-fixed, paraffin-embedded tumor

Dataset Format(s)
PDF, XML, gzip, TXT
Dataset Size
197.94 KB
Data Catalog Record Updated
2024-07-12