Molecular Epidemiology of Colorectal Cancer (MECC) Metastasis Study: A Germline Variant on Chromosome 4q31.1 Associates with Susceptibility to Developing Colon Cancer Metastasis

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UID: 11308

Author(s): Gruber, Stephen B., Rennert, Gad, Markowitz, Sanford D.

Description: Description from dbGaP:

"This study compared Ashkenazi Jewish individuals with Stage IV metastatic colon cancer to those with non-metastatic Stage I or II colon cancers. A genome-wide association study, using a 2-stage design, identified a significant association with rs60745952."

Subject of Study

Subject(s)

Access via dbGaP

Accession #: phs001045.v1.p1
Access Restrictions: Application Required
Access Instructions: Full access to this dataset in dbGaP requires authorization through an Authorized Access Portal which can be requested for either 'data download' or 'view only'. Individual level data download requires a project request. With dbGaP DataBrowser approval, users may view the compilation of individual-level data of general research use. Upon approval, data can be downloaded. To view the data available with Authorized Access, click the link 'list of components' in the Authorized Access section. Upon approval, data can be downloaded.

Publicly available data such as data dictionaries, variable summaries, documents and truncated analysis are available the public download site FTP link.
Associated Publications: Markowitz S, Nock N, Schmit S, Stadler Z, Joseph V, Zhang L, Willis J, Scacheri P, Veigl M, Adams M, Raskin L, Sullivan J, Stratton K, Shia J, Ellis N, Rennert H, Manschreck C, Li L, Offit K, Elston R, Rennert G, Gruber S. A germline variant on chromosome 4q31.1 associates with susceptibility to developing colon cancer metastasis. PLoS ONE. 2016; 11(1):e0146435.
Equipment Used: Illumina HumanOmniExpressExome-8v1
Dataset Format(s): PDF, XML, TAR, gzip, TXT
Dataset Size: 60.67 MB

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