Transcriptome change mediated by tumor-intrinsic PRC2 inactivation in transplant murine breast cancer AT3 tumor model in C57BL/6J mice

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UID: 11318

Author(s): Chi, Ping*, Chen, Yuedan*, Yan, Juan*, Chen, Yu* * MSK affiliated

Description: Description from GEO:

"We used CRISPR/Cas9-mediated knockout of PRC2 core components, Eed and generated PRC2-isogenic murine mammary tumor model (AT3, sgCon vs. sgEed ) amenable for syngeneic transplant in C57BL/6J mice. Transcriptome analysis of the explanted PRC2-wt (sgCon) and PRC2-loss (sgEed) AT3 tumors by RNA-seq demonstrated that PRC2 loss led to the upregulation of various developmental pathways, and the downregulation of both innate and adaptive immune response pathways."

Overall design from GEO:

"mRNA profiles of AT3 sgCon and sgEed tumors after mammary fat pad grafting in C57BL/6J mice"

Subject of Study

Subject(s)

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