The chromatin accessibility change by PRC2 inactivation with or without IFNγ stimulation in human MPNST cancer cells

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UID: 11329

Author(s): Chi, Ping*, Chen, Yu*, Yan, Juan*, Patel, Amish J.* * MSK affiliated

Description: Description from GEO:

"PRC2-isogenic human malignant peripheral nerve sheath tumor (MPNST) M3 cells were generated through CRISPR/Cas9-mediated knockout of the PRC2 core component, SUZ12. PRC2 loss led to not only significant increase, but also significant decrease of chromatin accessibility at 15,346 (16% of all ATAC peaks) and 20,099 genomic loci (21% of all ATAC peaks), respectively. PRC2 loss decreased the chromatin accessibility for IFNγ-responsive loci in M3 cells, resulting in dampened response to IFNγ stimulation."

Overall design from GEO:

"PRC2-isogenic human MPNST M3 cells (sgCon, sgSUZ12) were treated with PBS or 10 ng/ml IFNγ stimulation for 24 hr, followed by chromatin accessibility profiling."

Subject of Study

Subject(s)

OncoTree Cancer Type(s)

Malignant Peripheral Nerve Sheath Tumor

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