Ribosome dynamics following arginine deprivation in colon cancer cells

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UID: 11349

Author(s): Hsu, Dennis J.* * MSK affiliated

Description: Summary from GEO:

"To investigate ribosome localization and gene expression dynamics during starvation in cancer cells, we performed RNA sequencing and ribosome profiling in RKO cells under fed and starved (12.5 uM arginine) conditions."

Overall design from GEO:

"Cells were kept under fed (400 uM arginine) or starved (12.5 uM arginine) conditions for 24 hours. RNA sequencing and ribosome profiling were performed concurrently following previously published protocols (PMID 28579404)"

Subject of Study

Subject(s)

Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus and BioProject databases provides open access to these files.
Associated Publications: Hsu D, Gao J, Yamaguchi N, Pinzaru A, Wu Q, Mandayam N, Liberti M, Heissel S, Alwaseem H, Tavazoie S, Tavazoie S. Arginine limitation drives a directed codon-dependent DNA sequence evolution response in colorectal cancer cells. Science Advances. 2023; 9(1):eade9120.
Equipment Used: Illumina NextSeq 500
Dataset Format(s): TXT
Dataset Size: 400 KB

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