A spatially resolved timeline of the human maternal-fetal interface

UID: 11359

Author(s): Averbukh, Inna, Soon, Erin

Description: Description from Figshare:

"Files Provided:
- denoised.zip,denoised1.zip: denoised MIBI images for the entire cohort. The images are divided into two archive files due to uploading file size limitations - we apologize for the inconvenience. The files are organized by field of view (FOV), with each FOV subfolder containing TIF images for each channel that have undergone low-level processing as described in the methods section “Low-level image processing”.

- mask_labeled.zip: labeled feature annotations for the entire cohort. These are organized by FOV, with each FOV subfolder containing individual TIFs for each annotated feature (arteries, vessels, glands) in the image (see Methods section “Feature annotation”). Features in each TIF have been assigned a unique label for downstream analyses.

- lineage_CPMs_for_cohort.zip: contains cell phenotype map (CPM) pseudo color overlays for the entire cohort. These are labeled by FOV, and each FOV shows the cell segmentation mask colored by cell lineage assignment (see Methods).

- cell_cell_and_cell_artery_spatial_enrichment_per_image.zip - cell-cell and cell-artery enrichment z-scores per image (see Methods)

- Single_cells_MIBI.csv.zip - a table enumerating all single cells in this study and provides their location, morphological characteristics (such as size and shape), marker expression, FlowSOM cluster assignment and cell type assignment

- Segmentation.zip: segmentation results per FOV, pixels value in each cell correspond to the cell label in the single cell table."

Subject of Study

Homo sapiens

Subject(s)

Arteries

Cell Lineage

Image Processing, Computer-Assisted

Maternal-Fetal Exchange

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