Genetic ancestry effects on the response to viral infection are pervasive but cell type specific

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UID: 11401

Author(s): Randolph, Haley E.

Description: Description from BioProject:

"Humans differ in their susceptibility to infectious disease, partly due to variation in the immune response following infection. We used single-cell RNA-sequencing to quantify variation in the response to influenza infection in peripheral blood mononuclear cells from European- and African-ancestry males. Genetic ancestry effects are common but highly cell type-specific. Higher levels of European ancestry are associated with increased type I interferon pathway activity in early infection, which predicts reduced viral titers at later time points. Substantial population associated variation is explained by cis-expression quantitative trait loci that are differentiated by genetic ancestry. Furthermore, genetic ancestry-associated genes are enriched among genes correlated with COVID-19 disease severity, suggesting that the early immune response contributes to ancestry-associated differences for multiple viral infection outcomes."

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