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Integrin-α10-dependency defines a novel therapeutic strategy targeting RAC and mTORC2 for metastatic myxofibrosarcoma

UID: 11423

Author(s): Lee, Ann Y.*, Okada, Tomoyo*, Agaram, Narasimhan*, Qin, Li-Xuan*, Socci, Nicholas D.*, Miller, Martin L.*, Agius, Phaedra*, Molinelli, Evan*, Tap, William*, Crago, Aimee M.*, Sander, Chris, Decarolis, Penelope*, Shen, Yawei*, O'Connor, Rachael*, Singer, Samuel* * MSK affiliated

Description
Summary from GEO:

"Analysis of U133A microarray data from 64 primary high-grade tumors identified ITGA10 as the gene most significantly associated with distant metastasis and poor disease-specific survival.
Further investigation using shRNA knockdown identifies the TRIO-RAC-PAK and RICTOR-mTORC2 pathways as important downstream signaling pathways for ITGA10."

Overall design from GEO:

"RNA samples were prepared from 64 primary high-grade myxofibrosarcoma tumors previously frozen in liquid nitrogen. A portion of each tumor was placed in a cryomold and slides were cut for review by our pathologist to confirm the diagnosis in each case. Areas of normal tissue and necrotic tumor were macrodissected based on slide review. Only areas of viable tumor were included for RNA extraction."
Subject of Study
Homo sapiens
Subject(s)
Fibrosarcoma
Integrin alpha Chains
Neoplasm Metastasis
Survival Analysis
Access via GEO


Accession #: GSE72545

Access via BioProject


Accession #: PRJNA294304

Access Restrictions
Free to All
Access Instructions
The NCBI Gene Expression Omnibus and BioProject databases provides open access to these files.
Associated Publications
Okada T, Lee A, Qin L, Agaram N, Mimae T, Shen Y, O’Connor R, López-Lago M, Craig A, Miller M, Agius P, Molinelli E, Socci N, Crago A, Shima F, Sander C, Singer S. Integrin-α10 dependency identifies RAC and RICTOR as therapeutic targets in high-grade myxofibrosarcoma. Cancer Discovery. 2016; 6(10):1148-1165.
Equipment Used
Affymetrix U133A array
Dataset Format(s)
TAR, CEL, CHP, TXT
Dataset Size
176.2 MB
Data Catalog Record Updated
2024-11-20