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DNA methylation sequencing profiles of 1538 breast tumors and 244 normal breast tissues

UID: 11439

Author(s): Karniely, Marion

Publisher(s): European Genome-phenome Archive

Description
Description from EGA:

"DNA methylation sequencing profiles of 1538 breast tumors and 244 normal breast tissues. Libraries were prepared using a custom Reduced Representation Bisulfite Sequencing pipeline. Sequencing was performed on the Illumina HiSeq 2500 (v4 chemistry), with single-end reads of 125 bp length. Multiplexing was conducted at the level of 8 samples per lane. FASTQ files are provided for 1538 breast tumors and 244 normal breast tissues.

Reference: Batra et al. (2021). DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation."

Part of the METABRIC data access committee study, accession number EGAC0000100048
Subject of Study
Homo sapiens
Subject(s)
Breast Neoplasms
DNA Methylation
Sequence Analysis
Access via EGA


Accession #: EGAD00001007976

Access Restrictions
Application Required
Access Instructions
The European Genome-Phenome Archive (EGA) provides a service for the permanent archiving and distribution of personally identifiable genetic and phenotypic data resulting from biomedical research projects. Data at EGA was collected from individuals whose consent agreements authorise data release only for specific research use to bona fide researchers. Strict protocols govern how information is managed, stored and distributed by the EGA project.

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Associated Publications
Bieging-Rolett K, Kaiser A, Morgens D, Boutelle A, Seoane J, Van Nostrand E, Zhu C, Houlihan S, Mello S, Yee B, McClendon J, Pierce S, Winters I, Wang M, Connolly A, Lowe S, Curtis C, Yeo G, Winslow M, Bassik M, Attardi L. Zmat3 is a key splicing regulator in the p53 tumor suppression program. Molecular Cell. 2020; 80(3):452-469.e9.
Equipment Used
Illumina HiSeq 2500

High throughput sequencing system

Dataset Format(s)
FASTQ, gzip
Dataset Size
3.6 TB
Data Catalog Record Updated
2025-01-03