Data Catalog
Description
Description from GitHub:

"ldsc is a command line tool for estimating heritability and genetic correlation from GWAS summary statistics. ldsc also computes LD Scores."
Subject of Study
Homo sapiens
Subject(s)
Genetic Association Studies
Genome-Wide Association Study
Multifactorial Inheritance
Access via GitHub

Access Restrictions
Free to All
Access Instructions
Free to download via GitHub. Licensed under GNU GPL v3. See GitHub page for preferred citation methods.
Associated Publications
Kim S, Truong B, Jagadeesh K, Dey K, Shen A, Raychaudhuri S, Kellis M, Price A. Leveraging single-cell ATAC-seq and RNA-seq to identify disease-critical fetal and adult brain cell types. Nature Communications. 2024; 15:563.
Finucane HK, Bulik-Sullivan B, Gusev A, Trynka G, Reshef Y, Loh PR, Anttila V, Xu H, Zang C, Farh K, Ripke S, Day FR; ReproGen Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium; RACI Consortium; Purcell S, Stahl E, Lindstrom S, Perry JR, Okada Y, Raychaudhuri S, Daly MJ, Patterson N, Neale BM, Price AL. Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat Genet. 2015 Nov;47(11):1228-35. Epub 2015 Sep 28.
Gazal S, Finucane HK, Furlotte NA, Loh PR, Palamara PF, Liu X, Schoech A, Bulik-Sullivan B, Neale BM, Gusev A, Price AL. Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection. Nat Genet. 2017 Oct;49(10):1421-1427. doi: 10.1038/ng.3954. Epub 2017 Sep 11. Erratum in: Nat Genet. 2019 Aug;51(8):1295.
Bulik-Sullivan, Brendan. (2015). Relationship between LD Score and Haseman-Elston Regression.
Zheng J, Erzurumluoglu AM, et al. LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis. Bioinformatics. 2017 Jan 15;33(2):272-279. Epub 2016 Sep 22.
Software Used
Anaconda

Python distribution and package manager

Dataset Format(s)
R, gzip, TXT, YML, PY, MD
Dataset Size
5.6 MB
Data Catalog Record Updated
2025-10-13