EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

Authors

Béguelin, Wendy

Teater, Matt

Elemento, Olivier

Melnick, Ari M.

Description

Summary from the GEO: "The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B-cells and targeted by somatic mutations in B-cell lymphomas. Here we find that EZH2 deletion or pharmacologic inhibition suppresses GC formation and functions in mice. EZH2 represses proliferation checkpoint genes and helps establish bivalent chromatin domains at key regulatory loci to transiently...

Subject

DNA Methylation

Gene Expression Profiling

Lymphoma, B-Cell

Lymphoma, Large B-Cell, Diffuse

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