Genomic Analyses of Flow-sorted Hodgkin Reed Sternberg Cells Reveal Complementary Mechanisms of Immune Evasion.

Authors

Shipp, Margaret A.

Getz, Gad

Description

Study Description from dbGaP: "Classical Hodgkin lymphoma (cHL) is composed of rare malignant Hodgkin Reed Sternberg (HRS) cells within an extensive, but ineffective, inflammatory/immune cell infiltrate. HRS cells exhibit near-universal somatic copy gains of chromosome 9p/9p24.1 which increase expression of the PD-1 ligands. To define genetic mechanisms of response and resistance to PD-1 blockade...

Subject

Herpesvirus 4, Human

Histocompatibility Antigens Class I

Hodgkin Disease

Immune Checkpoint Inhibitors

NF-kappa B

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