AICDA-induced epigenetic plasticity accelerates germinal center-derived lymphomagenesis

Authors

Teater, Matt

Elemento, Olivier

Melnick, Ari M.

Description

Summary from the GEO: "Epigenetic heterogeneity is emerging as a significant phenotypic feature of tumors. In diffuse large B-cell lymphomas (DLBCLs), increased cytosine methylation heterogeneity is associated with poor clinical outcome, yet the biological mechanisms driving epigenetic heterogeneity remain unclear. Activation-induced cytidine deaminase (AICDA), an enzyme that deaminates and facilitates...

Subject

Cytidine Deaminase

Germinal Center

Lymphoma, Large B-Cell, Diffuse

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