Summary from the GEO: "The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B-cells and targeted by somatic mutations in B-cell lymphomas. Here we find that EZH2 deletion or pharmacologic inhibition suppresses GC formation and functions in mice. EZH2 represses proliferation checkpoint genes and helps establish bivalent chromatin domains at key regulatory loci to transiently...

This dataset contains the summary data visualizations and clinical data from targeted sequencing of 34 lymphoma cell lines from 34 patients using HemePACT_v3. Clinical data includes: Cancer Type, Mutation Count, Fraction Genome Altered, Sex, Collaboration Id, Oncotree Code, Specimen Preservation Type, Tissue Site. The plaintext components of the dataset can be downloaded as a tar file. The clinical...

Summary from the GEO: "Epigenetic heterogeneity is emerging as a significant phenotypic feature of tumors. In diffuse large B-cell lymphomas (DLBCLs), increased cytosine methylation heterogeneity is associated with poor clinical outcome, yet the biological mechanisms driving epigenetic heterogeneity remain unclear. Activation-induced cytidine deaminase (AICDA), an enzyme that deaminates and facilitates...