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  • EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

    Béguelin, Wendy
    Teater, Matt
    Elemento, Olivier
    Melnick, Ari M.

    Summary from the GEO: "The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B-cells and targeted by somatic mutations in B-cell lymphomas. Here we find that EZH2 deletion or pharmacologic inhibition suppresses GC formation and functions in mice. EZH2 represses proliferation checkpoint genes and helps establish bivalent chromatin domains at key regulatory loci to transiently...

    DNA Methylation
    Gene Expression Profiling
    Lymphoma, B-Cell
    Lymphoma, Large B-Cell, Diffuse
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