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  • AICDA-induced epigenetic plasticity accelerates germinal center-derived lymphomagenesis

    Teater, Matt
    Elemento, Olivier
    Melnick, Ari M.

    Summary from the GEO: "Epigenetic heterogeneity is emerging as a significant phenotypic feature of tumors. In diffuse large B-cell lymphomas (DLBCLs), increased cytosine methylation heterogeneity is associated with poor clinical outcome, yet the biological mechanisms driving epigenetic heterogeneity remain unclear. Activation-induced cytidine deaminase (AICDA), an enzyme that deaminates and facilitates...

    Cytidine Deaminase
    Germinal Center
    Lymphoma, Large B-Cell, Diffuse
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