USP8 and TP53 drivers are associated with CNV in a corticotroph adenoma cohort enriched for aggressive tumors

Authors

Uzilov, Andrew

Geer, Eliza

Description

Summary from Dryad: "Abstract: Context: Pituitary corticotroph adenomas are rare tumors that can be associated with excess adrenocorticotropic hormone (ACTH) and adrenal cortisol production, resulting in the clinically debilitating endocrine condition Cushing disease. A subset of corticotroph tumors behave aggressively, and genomic drivers behind the development of these tumors are largely unknown....

Subject

ACTH-Secreting Pituitary Adenoma

Adrenocorticotropic Hormone

Exome Sequencing

Genomics

Pituitary ACTH Hypersecretion

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