LY6E is a pan-coronavirus restriction factor in the respiratory tract

Authors

Mar, Katrina

Wells, Alexandra I.

Caballero Van Dyke, Marley C.

Lopez, Alexandra H.

6 more author(s)...

Description

Summary from GEO: "LY6E is an antiviral restriction factor that inhibits coronavirus spike-mediated fusion, but the cell types in vivo that require LY6E for protection from respiratory coronavirus infection are unknown. Here, we used a panel of seven conditional Ly6e knockout mice to define which Ly6e-expressing cells confer control of airway infection by murine coronavirus and SARS-CoV-2. Loss...

Subject

Antiviral Agents

Antiviral Restriction Factors

Epithelial Cells

Respiratory Tract Infections

SARS-CoV-2

Sequence Analysis, RNA

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