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De novo deletions and duplications at recombination hotspots in mouse germlines
- Authors
- Lukaszewicz, AgnieszkaKeeney, ScottJasin, Maria
- Description
Summary from GEO: "Numerous DNA double-strand breaks (DSBs) arise during meiosis to initiate homologous recombination. These DSBs are usually repaired faithfully, but here we uncover a new type of mutational event in which deletions form via joining of ends from two closely-spaced DSBs (double cuts) within a single hotspot or at adjacent hotspots on the same or different chromatids. Deletions occur...
- Subject
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Ataxia Telangiectasia Mutated ProteinsDNA Breaks, Double-StrandedMeiosisMutagenesis, InsertionalRecombination, Genetic
- Access Rights
- Free to All
