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  • Center for Common Disease Genomics [CCDG] - Autoimmune: Inflammatory Bowel Disease (IBD) Exomes and Genomes

    Authors
    Daly, Mark
    Description

    Description from dbGaP: "The National Human Genome Research Institute (NHGRI) has funded a collaborative large-scale genome sequencing effort to comprehensively identify rare risk and protective variants contributing to multiple common disease phenotypes. Called the Centers for Common Disease Genomics (CCDG), this initiative will explore a range of diseases with the ultimate goal of: undertaking...

    Subject
    Autoimmune Diseases
    Cardiovascular Diseases
    Genetic Association Studies
    Inflammatory Bowel Diseases
    Nervous System Diseases
    Whole Genome Sequencing
    Access Rights
    Free to All
  • Single-cell RNA-sequencing reveals pervasive but highly cell type-specific genetic ancestry effects on the response to viral infection

    Authors
    Randolph, Haley E.
    Fiege, Jessica K.
    Thielen, Beth K.
    Cobb, M.S.
    3 more author(s)...
    Description

    Description from GEO: "Humans show remarkable variation in susceptibility to infectious diseases as well as chronic inflammatory and autoimmune disorders. This heterogeneity arises partially from variation in the immune response, which is responsible for preventing and controlling infection. To better understand the major factors driving antiviral immune response differences, we used single-cell...

    Subject
    Autoimmune Diseases
    Inflammation
    Influenza A virus
    Influenza, Human
    Leukocytes, Mononuclear
    Single-Cell Gene Expression Analysis
    Access Rights
    Free to All