IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice I

Authors

Song, Qingxiao

Zeng, Defu

Description

Summary from the GEO: "CD4+ and CD8+ T cells can reciprocally differentiate into Th/Tc1, Th/Tc17 and Th/Tc22. Although alloreactive Th/Tc1 cells play a critical role in initiating pathogenesis of gut acute graft-versus-host disease (Gut-aGVHD), the pathogenic T cells in steroid-resistant Gut-aGVHD (SR-Gut-aGVHD) remains unclear. Here, we show that in murine models of SR-Gut-aGVHD, the pathogenesis...

Subject

Bacterial Translocation

CD8-Positive T-Lymphocytes

Chemokines, CX3C

Dysbiosis

Graft vs Host Disease

Interleukin-17

Interleukins

Phagocytes

Programmed Cell Death 1 Receptor

T-Lymphocytes, Cytotoxic

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