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  • Small Cell Carcinoma of the Ovary (MSK, Nat Genet 2014): Targeted sequencing of 12 SCCO paired tumor and normal samples.

    Authors
    Jelinic, Petar
    Mueller, Jennifer J.
    Olvera, Narciso
    Dao, Fanny
    8 more author(s)...
    Description

    Targeted sequencing of small cell carcinoma of the ovary, a rare, highly aggressive form of ovarian cancer primarily diagnosed in young women. This dataset contains visual summaries and clinical data from 12 patients. Data includes molecular profiles, information on mutations, and patient demographics.

    Subject
    Carcinoma, Small Cell
    Ovarian Neoplasms
    Access Rights
    Free to All
  • Genome Sequencing Reveals That RAD50 Hypomorphism Results in Enhanced Sensitivity to Checkpoint Kinase Inhibition Combined with Chemotherapy

    Authors
    Taylor, Barry Stephen
    Solit, David
    Petrini, John
    Description

    From the dbGaP study description: "Outlier analyses represent a versatile method to identify predictive biomarkers of response to both targeted agents and chemotherapy. We performed whole genome sequencing (WGS) of tumor and germline blood from a patient with metastatic small cell carcinoma of the ureter who experienced a durable complete response to a combination of irinotecan plus AZD7762, a checkpoint...

    Subject
    Carcinoma, Small Cell
    Drug Therapy
    Genomics
    Immune Checkpoint Inhibitors
    Protein Kinase Inhibitors
    Whole Genome Sequencing
    Access Rights
    Application Required