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Small Cell Carcinoma of the Ovary (MSK, Nat Genet 2014): Targeted sequencing of 12 SCCO paired tumor and normal samples.
- Authors
- Jelinic, PetarMueller, Jennifer J.Olvera, NarcisoDao, Fanny8 more author(s)...
- Description
Targeted sequencing of small cell carcinoma of the ovary, a rare, highly aggressive form of ovarian cancer primarily diagnosed in young women. This dataset contains visual summaries and clinical data from 12 patients. Data includes molecular profiles, information on mutations, and patient demographics.
- Subject
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Carcinoma, Small CellOvarian Neoplasms
- Access Rights
- Free to All
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Genome Sequencing Reveals That RAD50 Hypomorphism Results in Enhanced Sensitivity to Checkpoint Kinase Inhibition Combined with Chemotherapy
- Authors
- Taylor, Barry StephenSolit, DavidPetrini, John
- Description
From the dbGaP study description: "Outlier analyses represent a versatile method to identify predictive biomarkers of response to both targeted agents and chemotherapy. We performed whole genome sequencing (WGS) of tumor and germline blood from a patient with metastatic small cell carcinoma of the ureter who experienced a durable complete response to a combination of irinotecan plus AZD7762, a checkpoint...
- Subject
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Carcinoma, Small CellDrug TherapyGenomicsImmune Checkpoint InhibitorsProtein Kinase InhibitorsWhole Genome Sequencing
- Access Rights
- Application Required