Modeling cancer-associated mutations reveals an integrated role for the Pol epsilon catalytic core in replisome assembly and DNA synthesis

Authors

Meng, Xiangzhou

Zhao, Xiaolan

Zhang, Tuo

Xiang, Jenny

Description

Summary from GEO: "DNA polymerase epsilon (Pol epsilon) plays multiple roles in genome duplication and its catalytic subunit POLE suppresses tumorigenesis in humans. Despite its importance, we have limited understanding of Pol epsilon functional mechanisms and how its loss-of-function affects the evolution of cancer genomes. To address this issue, we used the budding yeast ortholog Pol2 to model...

Subject

Carcinogenesis

Catalytic Domain

DNA Polymerase II

Tumor Suppressor Proteins

Access Rights

Free to All