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  • Senescence rewires microenvironment sensing to facilitate anti-tumor immunity (bulk RNA-Seq)

    Authors
    Chen, Hsuan-An
    Ho, Yu-jui
    Mezzadra, Riccardo
    Adrover, Jose M.
    10 more author(s)...
    Description

    Summary from GEO: "Cellular senescence involves a stable cell cycle arrest coupled to a secretory program that, in some instances, stimulates the immune clearance of senescent cells. Using an immune competent tumor model in which senescence triggers CD8 T cell-mediated tumor rejection, we show that senescence also remodels cell surface proteome to alter how they sense environmental factors, as exemplified...

    Subject
    CD8-Positive T-Lymphocytes
    Cell Cycle Checkpoints
    Cellular Senescence
    RNA-Seq
    Tumor Suppressor Protein p53
    Access Rights
    Free to All

  • Senescence rewires microenvironment sensing to facilitate anti-tumor immunity (scRNA-Seq)

    Authors
    Chen, Hsuan-An
    Alonso-Curbelo, Direna
    Lowe, Scott W.
    Description

    Summary from GEO: "Cellular senescence involves a stable cell cycle arrest coupled to a secretory program that, in some instances, stimulates the immune clearance of senescent cells. Using an immune competent tumor model in which senescence triggers CD8 T cell-mediated tumor rejection, we show that senescence also remodels cell surface proteome to alter how they sense environmental factors, as exemplified...

    Subject
    CD8-Positive T-Lymphocytes
    Cell Cycle Checkpoints
    Cellular Senescence
    RNA-Seq
    Tumor Suppressor Protein p53
    Access Rights
    Free to All