Summary from GEO: "Lineage tracing provides unprecedented insights into the fate of individual cells and their progeny in complex organisms. While effective genetic approaches have been developed in vitro and in animal models, these cannot be used to interrogate human physiology in vivo. Instead, naturally occurring somatic mutations have been utilized to infer clonality and lineal relationships...

Summary from GEO: "Lineage tracing provides unprecedented insights into the fate of individual cells and their progeny in complex organisms. While effective genetic approaches have been developed in vitro and in animal models, these cannot be used to interrogate human physiology in vivo. Instead, naturally occurring somatic mutations have been utilized to infer clonality and lineal relationships...

Summary from GEO: "Lineage tracing provides unprecedented insights into the fate of individual cells and their progeny in complex organisms. While effective genetic approaches have been developed in vitro and in animal models, these cannot be used to interrogate human physiology in vivo. Instead, naturally occurring somatic mutations have been utilized to infer clonality and lineal relationships...

Summary from GEO: "The inherent plasticity of tumor cells provides a mechanism of resistance to many molecularly targeted therapies, exemplified by adeno-to-neuroendocrine lineage transitions seen in prostate and lung cancer. Here we investigate the root cause of this lineage plasticity in a primary murine prostate organoid model that mirrors the lineage transition seen in patients. These cells lose...

Description from Figshare: "Processed data for CUT&RUN of isogenic SMARCA4-WT and -KO cell lines"

Description from Figshare: "Processed data for bulk ATAC-seq of isogenic SMARCA4-WT and -KO cell lines"

Description from Figshare: "Processed data for bulk RNA-seq of primary tumors isolated from KP, KPS-HET and KPS animals"

Description from Figshare: "Processed data for bulk RNA-seq of isogenic SMARCA4-WT and -KO cell lines"

Description from Figshare: "Mutations and copy number alterations in PDX models used in this study"

Summary from GEO: "The mechanisms underlying oncogenesis in desmoid-type fibromatosis are poorly understood. This project sought to understand how β-catenin may function to promote desmoid formation and how external signaling by PDGFRβ modulates this activity. To examine this question, RNA-seq was performed on CTNNB1 knock-downs. Gene set enrichment analysis suggested that the oncogene controlled...