Summary from GEO: "In pancreatic cancer, select cells within a homogeneous epithelium drive tumorigenesis in response to an environmental trigger, suggesting key uncharacterized roles for epigenetics and cellular context. To investigate epigenetic plasticity in early tumorigenesis, we performed single-cell transcriptional and chromatin accessibility sequencing of Kras-mutant pancreatic cancer models,...

Summary from GEO: "In pancreatic cancer, select cells within a homogeneous epithelium drive tumorigenesis in response to an environmental trigger, suggesting key uncharacterized roles for epigenetics and cellular context. To investigate epigenetic plasticity in early tumorigenesis, we performed single-cell transcriptional and chromatin accessibility sequencing of Kras-mutant pancreatic cancer models,...

Summary from GEO: "In pancreatic cancer, select cells within a homogeneous epithelium drive tumorigenesis in response to an environmental trigger, suggesting key uncharacterized roles for epigenetics and cellular context. To investigate epigenetic plasticity in early tumorigenesis, we performed single-cell transcriptional and chromatin accessibility sequencing of Kras-mutant pancreatic cancer models,...

Summary from GEO: "Pancreatic ductal adenocarcinoma (PDAC) portends a dire prognosis. Intra-tumoral heterogeneity and cellular plasticity have emerged as hallmarks of cancer, including PDAC. Yet, our understanding of the mechanisms underpinning cellular diversity in PDAC remains limited. Here, we investigate cellular heterogeneity of PDAC cancer cells across a range of in vitro and in vivo growth...

Description from GitHub: "We used droplet-based single-cell RNA sequencing (scRNA-seq) and graph-based phenotypic analysis to explore tumor cell heterogeneity through the lens of epithelial regeneration in lung cancer metastasis, and to assess parallels between tumor cell plasticity and developmental hierarchies. Using patient tumors as well as a mouse model of lung cancer metastasis, our analyses...

Code for data analysis and visualization from "Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis," (Burdziak et. al.). Includes a notebook with the full basic analysis of the PDAC progression data. See article for more information.