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  • scRNA-seq analysis of SARS-CoV-2 infected human islets

    Authors
    Chen, Shuibing
    Tang, Xuming
    Uhl, Skyler
    Description

    Summary from the GEO: "Recent clinical data has suggestedsed a bi-directional relationship between Coronavirus disease 19 (COVID-19) and diabetes. Here, we showdemonstrateed the detection of SARS-CoV-2 in pancreatic endocrine cells in autopsy samples derived fromof COVID-19 patients. Single cell RNA-seq and immunostaining confirmed that multiple types of pancreatic islet cells can be infected byare...

    Subject
    Chemokines
    COVID-19
    Eukaryotic Initiation Factor-2
    Islets of Langerhans
    Access Rights
    Free to All
  • R Script for the analysis of "SARS-CoV-2 Infection Induces Beta Cell Transdifferentiation "

    Authors
    Zhang, Tuo
    Chen, Shuibing
    Description

    Summary from GitHub: This repository contains the R scripts necessary to perform the analysis in our paper Tang, Xuming et al. “SARS-CoV-2 Infection Induces Beta Cell Transdifferentiation.” Cell Metabolism, 19 May. 2021, doi:10.1016/j.cmet.2021.05.015, as described in the supplementary methods and main text." Input data: "The single cell RNA-seq data were generated with the 10X Chromium and pre-processed...

    Subject
    Chemokines
    COVID-19
    Diabetes Mellitus
    Eukaryotic Initiation Factor-2
    Access Rights
    Free to All