ISG15 Conjugation to Proteins on Nascent DNA Mitigates DNA Replication Stress

Authors

Li, Zhuoning

Petrini, John

Description

Description from PRIDE: "The pathways involved in suppressing DNA replication stress and the associated DNA damage are critical to maintaining genome integrity. The Mre11 complex is unique among double strand break (DSB) repair proteins for its association with the DNA replication fork. Here we show that Mre11 complex inactivation causes DNA replication stress and changes in the abundance of proteins...

Subject

DNA Breaks, Double-Stranded

DNA Damage

DNA Repair

DNA Replication

MRE11 Homologue Protein

Access Rights

Free to All