DPP9 activity and not protein binding inhibits the CARD8 inflammasome

Authors

Griswold, Andrew

Bachovchin, Daniel

Description

Inflammasomes are multiprotein complexes formed in response to pathogens. NLRP1 and CARD8 are related proteins that form inflammasomes, but the pathogen-associated signal(s) and the molecular mechanisms controlling their activation have not been established. Inhibitors of the serine dipeptidyl peptidases DPP8 and DPP9 (DPP8/9) were recently discovered to activate both NLRP1 and CARD8. Interestingly,...

Subject

CARD Signaling Adaptor Proteins

Dipeptidyl-Peptidases and Tripeptidyl-Peptidases

Inflammasomes

Mass spectrometry

Protein Binding

Proteomics

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