EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

Authors

Chibaya, Loretah

Murphy, Katherine C.

DeMarco, Kelly D.

Gopalan, Sneha

17 more author(s)...

Description

Summary from GEO: "Immunotherapies that produce durable responses in some malignancies have failed in pancreatic ductal adenocarcinoma (PDAC) due to rampant immune suppression and poor tumor immunogenicity. We and others have demonstrated that induction of the senescence-associated secretory phenotype (SASP) can be an effective approach to activate anti-tumor Natural Killer (NK) and T cell immunity....

Subject

Carcinoma, Pancreatic Ductal

Enhancer of Zeste Homolog 2 Protein

Pancreatic Neoplasms

RNA-Seq

Senescence-Associated Secretory Phenotype

T-Lymphocytes

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