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  • Frequent 4EBP1 amplification induces synthetic dependence on FGFR signaling in cancer

    Authors
    Mohan, Prathibha
    Pasion, Joyce
    Lailler, Nathalie
    de Stanchina, Elisa
    6 more author(s)...
    Description

    Summary from GEO: "The eIF4E translation initiation factor has oncogenic properties and concordantly, the inhibitory eIF4E-binding protein (4EBP1) is considered a tumor suppressor. The exact molecular effects of 4EBP1 activation in cancer are still unknown. Surprisingly, 4EBP1 is a target of genomic copy number gains (Chr. 8p11) in breast and lung cancer. We notice that 4EBP1 gains are genetically...

    Subject
    Doxycycline
    Eukaryotic Initiation Factor-4E
    MicroRNAs
    Ribosome Profiling
    Tumor Suppressor Proteins
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