Substrate discrimination and quality control require each catalytic activity of TRAMP and the nuclear RNA exosome

Authors

Das, Mom

Zattas, Dimitrios

Lima, Christopher D.

Description

Summary from the GEO: "Abstract: Quality control requires discrimination between functional and aberrant species to selectively target substrates for destruction. Nuclear RNA quality control in Saccharomyces cerevisiae includes the TRAMP complex that marks RNA for decay via polyadenylation and helicase-dependent 3′ to 5′ degradation by the RNA exosome. Using reconstitution biochemistry we show that...

Subject

Exoribonucleases

Exosome Multienzyme Ribonuclease Complex

Receptors, Tumor Necrosis Factor, Member 25

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