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Profiling murine gut influence on peripheral tolerance
- Description
Summary from the ENA: "Antibiotic exposure early in life, and other practices impacting the vertical transmission and ordered assembly of a diverse and balanced gut microbiota, are associated with a higher risk of immunological and metabolic disorders such as asthma and allergy, autoimmunity, obesity, and susceptibility to opportunistic infections. Here, we use a model of perinatal exposure to the...
- Subject
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CD4-Positive T-LymphocytesDysbiosisForkhead Transcription FactorsMicrobiotaT-Lymphocytes, Regulatory
- Access Rights
- Free to All
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Foxp3-dependent and -independent functions of peripherally-induced Treg cells [08075]
- Authors
- van der Veeken, JorisCampbell, Clarissa M.Pritykin, YurySchizas, Michail8 more author(s)...
- Description
Summary from GEO: "Regulatory T (Treg) cells expressing the lineage-defining transcription factor Foxp3 are essential for the maintenance of immune tolerance. Foxp3 expression can be induced in a subset of developing self-reactive thymocytes to yield thymic Treg (tTreg) cells, critical for tolerance against self-antigens. Alternatively, activation of mature naïve T cells under non-inflammatory conditions...
- Subject
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Forkhead Transcription FactorsImmune ToleranceT-Lymphocytes, Regulatory
- Access Rights
- Free to All
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Foxp3-dependent and -independent functions of peripherally-induced Treg cells [09748]
- Authors
- van der Veeken, JorisCampbell, Clarissa M.Pritykin, YurySchizas, Michail8 more author(s)...
- Description
Summary from GEO: "Regulatory T (Treg) cells expressing the lineage-defining transcription factor Foxp3 are essential for the maintenance of immune tolerance. Foxp3 expression can be induced in a subset of developing self-reactive thymocytes to yield thymic Treg (tTreg) cells, critical for tolerance against self-antigens. Alternatively, activation of mature naïve T cells under non-inflammatory conditions...
- Subject
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Forkhead Transcription FactorsImmune ToleranceT-Lymphocytes, Regulatory
- Access Rights
- Free to All
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Foxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification [ChIP-Seq]
- Authors
- Samstein, Robert M.Arvey, AaronRudensky, Alexander Y.
- Description
Summary from GEO: "Regulatory T (Treg) cells, whose identity and function are defined by the transcription factor Foxp3, are indispensable for immune homeostasis. It is unclear whether Foxp3 exerts its Treg lineage specification function through active modification of the chromatin landscape and establishment of new enhancers or by exploiting a pre-existing enhancer landscape. Analysis of the chromatin...
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Chromatin Immunoprecipitation SequencingForkhead Transcription FactorsHomeostasis/immunologyT-Lymphocytes, Regulatory
- Access Rights
- Free to All
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Foxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification [Expression]
- Authors
- Samstein, Robert M.Arvey, AaronRudensky, Alexander Y.
- Description
Summary from GEO: "Regulatory T (Treg) cells, whose identity and function are defined by the transcription factor Foxp3, are indispensable for immune homeostasis. It is unclear whether Foxp3 exerts its Treg lineage specification function through active modification of the chromatin landscape and establishment of new enhancers or by exploiting a pre-existing enhancer landscape. Analysis of the chromatin...
- Subject
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Forkhead Transcription FactorsGene ExpressionHomeostasis/immunologyT-Lymphocytes, Regulatory
- Access Rights
- Free to All
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Novel Foxo1-dependent Transcriptional Programs Control Treg Cell Function [Affymetrix gene expression data]
- Authors
- Ouyang, WeimingLiao, WillLuo, Chong T.Yin, Na12 more author(s)...
- Description
Summary from GEO: "Regulatory T (Treg) cells characterized by expression of the transcription factor forkhead box P3 (Foxp3) maintain immune homeostasis by suppressing self-destructive immune responses1-4. Foxp3 operates as a late acting differentiation factor controlling Treg cell homeostasis and function5, whereas the early Treg cell lineage commitment is regulated by the Akt kinase and the forkhead...
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Binding sitesForkhead Transcription FactorsGene DeletionGene ExpressionT-Lymphocytes, Regulatory
- Access Rights
- Free to All
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Novel Foxo1-dependent Transcriptional Programs Control Treg Cell Function [ChIP-Seq]
- Authors
- Ouyang, WeimingLiao, WillLuo, Chong T.Yin, Na12 more author(s)...
- Description
Summary from GEO: "Regulatory T (Treg) cells characterized by expression of the transcription factor forkhead box P3 (Foxp3) maintain immune homeostasis by suppressing self-destructive immune responses1-4. Foxp3 operates as a late acting differentiation factor controlling Treg cell homeostasis and function5, whereas the early Treg cell lineage commitment is regulated by the Akt kinase and the forkhead...
- Subject
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Binding sitesChromatin Immunoprecipitation SequencingForkhead Transcription FactorsGene DeletionT-Lymphocytes, Regulatory
- Access Rights
- Free to All