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  • MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells

    Authors
    Mueller, Iris
    Moroni, Ann Sophie
    Shlyueva, Daria D.
    Sahadevan, Sudeep
    7 more author(s)...
    Description

    Summary from the GEO: "Deciphering the mechanisms that control the pluripotent ground state is key for understanding embryonic development. Nonetheless, the epigenetic regulation of ground-state mouse embryonic stem cells (mESCs) is not fully understood. Here, we identify the epigentic protein MPP8 as being essential for ground-state pluripotency. Its depletion leads to cell cycle arrest and spontaneous...

    Subject
    Gene Knock-In Techniques
    Mouse Embryonic Stem Cells
    Phosphoproteins
    Pluripotent Stem Cells
    Access Rights
    Free to All

  • Proteomics Data for "MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells"

    Authors
    Helin, Kristian
    Schoof, Erwin M.
    Description

    Description from protemoeXchange: "Deciphering the mechanisms that control the pluripotent ground state is key for understanding embryonic development. Nonetheless, the epigenetic regulation of ground-state mouse embryonic stem cells (mESCs) is not fully understood. Here, we identify the epigenetic protein MPP8 as being essential for ground-state pluripotency. Its depletion leads to cell cycle arrest...

    Subject
    Gene Knock-In Techniques
    Mouse Embryonic Stem Cells
    Phosphoproteins
    Pluripotent Stem Cells
    Access Rights
    Free to All