Summary from the GEO: "Linker histone H1 proteins bind to nucleosomes and cause chromatin compaction, although little is known about their biological functions. Histone H1 (HIST1H1B-E) mutations are highly recurrent in B-cell lymphomas and are present in solid tumors, but their cancer relevance and mechanism are unknown. Here we report that lymphoma-associated H1 alleles are genetic driver mutations...

Summary from GEO: "To investigate the effect of KRASi treatment on transcriptional output, we sequenced RNAs from 22 cell lines with different KRAS genotypes. We then performed gene expression profiling analysis using data obtained from RNA-seq comparing untreated and 2hr treated samples." Overall design from GEO: "Comparative gene expression profiling analysis of RNA-seq data for cells with...

Summary from GEO: "The inherent plasticity of tumor cells provides a mechanism of resistance to many molecularly targeted therapies, exemplified by adeno-to-neuroendocrine lineage transitions seen in prostate and lung cancer. Here we investigate the root cause of this lineage plasticity in a primary murine prostate organoid model that mirrors the lineage transition seen in patients. These cells lose...