Summary from GEO: "To study the low protein diet and cancer genetic effect on the macrophage in tumor, we treated the control-PyMT and S100a8-creRosa26-LSL-MYCPyMT (MYC-PyMT) mice reconstituted with wt bone marrow with low protein diet for 6 weeks." Overall design from GEO: "Compare the gene expression between TAMs and MTMs isolated by FACS from tumor of control-PyMT and MYC-PyMT mice treated...

Summary from GEO: "S100a8-cre driven expression of Rosa26-LSL-MYC in mouse PyMT cancer cells." Overall design from GEO: "Bulk tumor tissues from control-PyMT and S100a8-creRosa26-LSL-MYCPyMT (MYC-PyMT) mice were collected and homogenized in liquid nitrogen for TRIZOL RNA extraction and RNAseq."

Summary from GEO: "Natural killer (NK) cells are critical mediators of host immunity against infectious disease and cancer. The intrinsic regulators of NK cells are not fully understood. Here, we demonstrate that the ER stress sensor inositol-requiring enzyme 1 (IRE1α) and its substrate transcription factor X-box-binding protein 1 (XBP1) critically drive NK cell-mediated responses against viral infection...