Synthetic introns enable mutation-dependent targeting of cancer cells

Authors

North, Khrystyna

Benbarche, Salima

Abdel-Wahab, Omar Ibrahim

Bradley, Robert K.

Description

Summary from GEO: "Many cancers carry recurrent change-of-function mutations in RNA splicing factor genes, which induce sequence-specific changes in RNA splicing. Here, we describe a method to harness this change in RNA splicing activity to drive splicing factor mutation-dependent gene expression in cancers and selectively eliminate these tumors. We engineered synthetic introns which were efficiently...

Subject

Breast Neoplasms

Epithelial Cells

Genetic Therapy

Introns/genetics

Leukemia

RNA Splicing Factors

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