Translation in amino acid-poor environments is limited by tRNAGln charging

Authors

Pavlova, Natalya N.

King, Bryan C.

Thompson, Craig B.

Description

Summary from the GEO: "An inadequate supply of amino acids leads to accumulation of uncharged tRNAs, which can bind and activate GCN2 kinase to reduce translation. Here, we show that glutamine-specific tRNAs selectively become uncharged when extracellular amino acid availability is compromised. In contrast, all other tRNAs retain charging of their cognate amino acids in a manner that is dependent...

Subject

Amino Acids

Glutamine

Peptides

RNA, Transfer, Gln

Access Rights

Free to All